The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review
John E. Lewis1*, Jillian Poles2, Delaney P. Shaw3, Elisa Karhu4, Sher Ali Khan5, Annabel E. Lyons6, Susana Barreiro Sacco7, H. Reginald McDaniel8
1Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA, 2 Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 3 Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA, 4 Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA, 5 Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA, 6 School of Nursing and Health Studies, University of Miami, Coral Gables, FL, USA, 7 Department of Internal Medicine, Mount Sinai Medical Center Miami Beach, FL, USA, 8 Wellness Quest, LLC, Grand Prairie, TX, USA
Background and Aim: Brain health is becoming more important to the average person as the number of people with cognitive impairments, such as Alzheimer’s disease (AD), is rising significantly. The current Food and Drug Administration-approved pharmacotherapeutics for dementia neither cure nor halt cognitive decline; they just delay the worsening cognitive impairment. This narrative review summarizes the effects of nutrients and phytonutrients on cognitive function.
Methods: A comprehensive literature search of PubMed was performed to find clinical trials in humans that assessed the effects of nutrients and phytonutrients on cognitive function published in English between 2000 and 2021. Six independent reviewers evaluated the articles for inclusion in this review.
Key words: Alzheimer’s disease, cognitive function, cognitive impairment, memory nutrients, phytonutrients