Sulforaphane: Expected to Become a Novel Antitumor Compound
Geting Wu,*1 Yuanliang Yan,†‡1 Yangying Zhou,§ Yumei Duan,* Shuangshuang Zeng,†‡ Xiang Wang,†‡ Wei Lin,* Chunlin Ou,* Jianhua Zhou,* and Zhijie Xu*‡
*Department of Pathology, Xiangya Hospital, Central South University, Changsha, P.R. China †Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, P.R. China ‡National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, P.R. China §Department of Oncology, Xiangya Hospital, Central South University, Changsha, P.R. China
Natural products are becoming increasingly popular in a variety of traditional, complementary, and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the antitumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate or inhibit related signaling pathways. SFE has exhibited promising inhibitory effects on breast cancer, lung cancer, liver cancer, and other malignant tumors. In this review, we summarized the reports on the activity and functional mechanisms of SFE in cancer treatment and explored the efficacy and toxicity of SFE.
Sulforaphane; Malignant tumor; Antitumor effects